Hybrid Bacteria System with Nanomaterials for Tumor Therapy

Recently, bacteria-mediated therapy has been widely applied for tumor treatments owing to some inherent features of bacteria. With further advancements in genetic engineering and nanotechnology, natural bacteria are endowed with extra capacities rational reprogramming, spatiotemporally precise manipulation, other exogenous characteristics. Hybrid systems leverage versatile nanomaterials modify the surface bacteria, which exhibit great potential solving existed problems traditional therapy, greatly improving therapeutic efficacy. Therefore, hybrid bacteria–based platforms present a promising strategy raise increasing attentions. In this review, based on different types chassis related organisms introduced, methodologies nanomaterial-modified systemically expounded. Moreover, promises as drug delivery vesicles cancer disease bioimaging, diagnosis discussed, followed by elaboration their perspectives challenges clinical translation.